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    Title: 中西醫合併大腸癌治療的存活分析;Survival Analysis of Combined Traditional Chinese and Western Medicine Therapy for Colorectal Cancer
    Authors: 高明源;KAO, MING-YUAN
    Contributors: 資訊工程研究所
    Keywords: 存活分析;Cox比例風險模型;中西醫合併治療;大腸癌;colorectal cancer;combined traditional Chinese and western medicine therapy;survival analysis;COX risk regression analysis
    Date: 2018
    Issue Date: 2019-05-23 10:30:26 (UTC+8)
    Publisher: 資訊工程研究所
    Abstract: 本論文分析中西醫合併治療的大腸癌病患和非中西醫治療的大腸癌病患的存活時間是否有顯著差異。研究首先從台北與大林慈濟醫院取得2003年至2016年的癌症登記資料庫與中醫門診紀錄資料庫,篩選出欲分析的病患資料共2064人,其中包括非中西醫組1777人、中西醫組287人。本論文先透過卡方檢定得知在許多研究變項上治療方式分布有顯著差異,因此無法直接運用Kaplan-Meier存活分析。本論文接著使用Cox比例風險模型來分析多個研究變項對存活率的影響,並且考慮研究變項之間是否存在交互作用。分析結果顯示中西醫相對於非中西醫的治療方式減少約54.6%的死亡風險,且達到顯著差異。此外,本論文也發現2個單味藥、6個方劑、1個方劑組合在治療大腸癌上有顯著的效果。本論文顯示使用中醫改善病患免疫力及減緩西醫治療副作用可以顯著延長大腸癌病患的存活時間。
    This thesis studies whether patients with colorectal cancer can prolong their survival through combined traditional Chinese medicine (TCM) and western medicine treatment. We collect the dataset from cancer registration database and Chinese medicine clinic records in Dalin and Taipei Tzu Chi Hospital for data between 2003 and 2016. This dataset includes 2064 valid patients, including 1777 non-TCM patients and 287 TCM patients. This thesis first uses the chi-square test to show that there are significant differences in the distribution of many research variables. Therefore, the Kaplan-Meier survival analysis cannot be directly applied. This thesis then uses the Cox risk regression analysis by stratifying the research variables that do not pass the PH assumption and identifying the research variables with interactions. The results of the analysis show that using the combined Chinese and western medicine treatment reduces 54.6% of the risk of death. In addition, the Cox risk regression analysis also identifies that 2 herbs, 6 formulas and 1 formula combination have significantly good effects in the treatment of colorectal cancer. This thesis shows that using TCM to improve body immunity and reduce side effects of western medicine treatment can significantly improve the survival time of colorectal cancer patients.
    Appears in Collections:[資訊工程學系] 學位論文

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