本研究團隊已研製一個中醫辨證系統及一個中醫藥材配伍系統。本論文在前兩個系統的基礎上，研製一個中醫方劑配伍系統。這三個系統實踐中醫「辨證論治」的資訊化。中醫辨證系統實踐中醫「辨證」的資訊化，目前支援67個證候。中醫方劑配伍系統及中醫藥材配伍系統協力實踐中醫「論治」的兩階段資訊化。第一個階段，中醫方劑配伍系統根據辨證的證候，推薦治療效力最強的方劑，目前支援186帖方劑。第二個階段，中醫藥材配伍系統根據辨證的證候及推薦的方劑，進行加減藥材，推薦治療效力最強的藥材，目前支援334味藥材。本論文也進行新增藥材及方劑的標準化，並依標準化的藥材及方劑更新中醫藥材知識本體及中醫藥材辭庫。本論文也訂定各方劑治療各證候的效力值，運用多目標最佳化技術，推薦治療多證候效力最強的方劑。 Our research team has developed a syndrome differentiation system and an medicinal combination system for traditional Chinese medicine (TCM). This thesis developes a formula combination system for TCM based on those two systems. These three systems apply the information technology to implement the framework of “syndrome differentiation and treatment” in TCM. The syndrome differentiation system implements the portion of “syndrome differentiation” and supports 67 syndromes currently. The formula combination system and the medicinal combination system collectively implement the portion of “syndrome treatment” using a two-stages approach. At the first stage, the formula combination system recommends the most effective formulas according to the syndromes identified by the syndrome differentiation system. It supports 186 formulas currently. At the second stage, the medicinal combination system allows practitioners to further add most effective medicine to or delete medicine from the selected formula. It supports 334 medicines currently. This thesis also standardizes new medicines and formulas, and updates the medicinal ontology and medicinal thesaurus accordingly. This thesis also sets the effectiveness of formulas for treating associated syndromes, and applies the multi-objective optimization technique to recommend the most effective formulas for multiple syndromes.